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Multiple sclerosis rates have increased significantly over the past 40 years. Genetics alone do not explain that trajectory.⁠ ⁠ The evidence points to environmental factors, including toxin exposure and chronic infections, interacting

High-sensitivity C-reactive protein (CRP) measurements were done using the ACE High Sensitivity C-Reactive Protein Reagent (ACI-22) for the first batch and the CRP (HS) Wide Range kit (Pointe Scientific) for the second batch on an ACE Clinical Chemistry System (Alfa Wassermann, Inc)

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Thus, it may be possible to selectively tune endogenous T cell responses by appropriate targeting of these co-stimulatory and co-inhibitory pathways